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中国化工论坛 » 专家技术 » [活动]有机化学家，名人，大腕巡礼

chemnews1 (杭州兔儿)
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06-05-23 08:41

[活动]有机化学家，名人，大腕巡礼

Elias James Corey

The Nobel Prize in Chemistry 1990

USA

Harvard University
Cambridge, MA, USA
[birth]. 1928
主页

[自传]http://nobelprize.org/chemistry/laureates/1990/corey-autobio.html

Nobel Lecture，December 8, 1990
http://nobelprize.org/chemistry/laureates/1990/corey-lecture.pdf

Prize for masterly development of organic synthesis

http://nobelprize.org/chemistry/laureates/1990/press.html

The development of the art of organic synthesis during little over a hundred years has afforded efficient methods of manufacturing products such as plastics and other artificial fibres, paints and dyes, biocides and pharmaceutical products, all of which have contributed to the high standards of living and health, and the longevity, enjoyed at least in the Western world.

This year's Nobel Prize in Chemistry has been awarded to Professor Elias J. Corey, USA, for his important contributions to synthetic organic chemistry. He has developed theories and methods that have made it possible to produce a large variety of biologically highly active, complicated natural products, thereby making, among other things, certain pharmaceuticals commercially available. Corey's work has also led to new general methods of producing, synthesising, compounds in simpler ways.

The background to Elias J. Corey's successes lies in the fact that he has in a strictly logical way developed the principles of what is termed retrosynthetic analysis. This involves starting from the planned structure of the molecule one wishes to produce, the target molecule, and analysing what bonds must be broken, thus simplifying the structure step by step. One then finds that certain fragments are already known and their structure and synthesis already described. After working backwards in this way from the complex to the already known, it is possible to start building, synthesising, the molecule. This method has proved very amenable to data processing, which has entailed rapid developments in synthesis planning. Combining this synthesis planning with singular creativity, Corey has developed new methods of synthesis. He has produced some hundred important natural products, for example the active substance in an extract from the ginkgo tree, used in folk medicine in China.

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06-05-23 08:43

Professor Stephen L. Buchwald

Department of Chemistry
Massachusetts Institute of Technology
Room 18-490
77 Massachusetts Avenue
Cambridge, MA 02139
USA

HOMEPAGE

Stephen L. Buchwald was born (1955), raised and received his precollege education in Bloomington, Indiana. He received his Sc.B. degree, Magna Cum Laude, in chemistry, from Brown University in 1977. During his undergraduate years he worked in the laboratories of Professors Kathlyn A. Parker and David E. Cane at Brown University and Professor Gilbert Stork at Columbia University.

He entered Harvard University as a National Science Foundation Predoctoral Fellow in 1977 and received his Ph.D. in 1982. His thesis work, under the supervision of Professor Jeremy R. Knowles, concerned the mechanism of phosphoryl transfer reactions in chemistry and biochemistry.

In early 1982 he took up a position as a Myron A. Bantrell postdoctoral fellow at the California Institute of Technology where he worked in the laboratory of Professor Robert H. Grubbs. His work at Caltech concerned the study of titanocene methylenes as reagents in organic synthesis. During this time he was also involved in work on the mechanism of Ziegler-Natta polymerization.

In 1984 he began as an assistant professor of chemistry at the Massachusetts Institute of Technology. He was promoted to the position of associate professor in 1989 and to Professor in 1993. He was named the Camille Dreyfus Professor of Chemistry in January of 1997. During his time at MIT he has received numerous honors including MIT's Harold Edgerton Faculty Achievement Award of MIT, an Arthur C. Cope Scholar Award, the 2000 Award in Organometallic Chemistry from the American Chemical Society, and a MERIT award from the National Institutes of Health. He has also been the recipient of the Bristol-Myers Squibb Distinguished Achievement Award and the CAS Science Spotlight Award, both recieved in 2005. In 2000, he was elected as a member in the American Academy of Arts and Sciences. He has been a named lecturer at a number of universities. He is the coauthor of 242 published or accepted papers and 25 issued patents. He serves as a consultant to Amgen, Merck, Rhodia Pharmaceutical Solutions, Lanxess, Englehard and Collegium Pharmaceuticals.

Research topics under investigation in his laboratories include:

1。Enantioselective Reduction
2。Carbon-Carbon Bond-Forming Reactions
3。Carbon-Heteroatom Bond-Forming Processes
4。The Design and Utilization of New Ligands
5。Applications in Total Synthesis

Recent Research Publications(2006-2004):

250. Buchwald, S. L.; Mauger, C.; Mignani, G.; Scholz, U. "Industrial-Scale Palladium-Catalyzed Coupling of Aryl Halides and Amines - A Personal Account."  Adv. Syn. & Cat. 2006, 348(1+2), 23-39.
249. Tundel, R.E.; Anderson, K.E.; Buchwald, S. L. "Expedited Palladium-Catalyzed Amination of Aryl Nonaflates Through the Use of Microwave-Irradiation and Soluble Organic Amine Bases." J. Org. Chem. 2006, 71, 430-433.
248. Hennessy, E.J.; Buchwald, S. L. "Synthesis of 4,5-Dianilinophthalimide and Related Analogs for Potential Treatment of Alzheimer's Disease via Palladium-Catalyzed Amination." J. Org. Chem. 2005, 70, 7371-7375.
247.  Vorogushin, A.V.; Huang, X.; Buchwald, S. L. "Use of Tunable Ligands Allows for Intermolecular Pd-Catalyzed C-O Bond Formation." J. Am. Chem. Soc. 2005, 127, 8146-8149.
246. Charles, M.D.; Schultz, P.; Buchwald, S. L. "Efficient Pd-Catalyzed Amination of Heteroaryl Halides." Org. Lett. 2005, 7, 3965-3968.
245. Rainka, M.P.;Milne, J.E.; Buchwald, S. L. "Dynamic Kinetic Resolution of a,b-Unsaturated Lactones Through Asymmetric Copper-Catalyzed Conjugate Reduction: Application to the Total Synthesis of Eupomatilone-3." Angew. Chemie Int. Ed. 2005, 44, 6177-6180
244. Anderson, K.W.; Buchwald, S. L."General Catalysts for the Suzuki-Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water." Angew. Chemie Int. Ed. 2005, 44, 6173-6177.
243. Tsang, W.C.; Zheng, Nan; Buchwald, S. L. "Combined C-H Functionalization/ C-N Bond Formation Route to Carbazoles." J. Am. Chem. Soc. 2005, 127, 14560-14561.
242. Strieter, E.R.; Blackmond, D.I.; Buchwald, S. L. "The Role of Chelating Ligands in the Goldberg Reaction: A Kinetic Study on the Copper-Catalyzed Amidation of Aryl Iodides."  J. Am. Chem. Soc. 2005, 127, 4120-4121.
241. Barder, T.E.; Walker, S.D.; Martinelli, J.R.; Buchwald, S. L. "New Catalysts for Suzuki-Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand Structure."J. Am. Chem. Soc. 2005, 127, 4685-4696
240. Chae, J.; Yun, J.; Buchwald, S. L. "One-Pot Sequential Cu-Catalyzed Reductions and Pd-Catalyzed Arylation of Silyl Enol Ethers." Org. Lett.2004, 6, 4809-4812
239. Milne, J.E.; Buchwald, S. L. "An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction." J. Am. Chem. Soc. 2004, 126, 13028-13032
238. Barder, T. E.; Buchwald, S. L. "Efficient Catalyst for the Suzuki-Miyaura Coupling of Potassium Aryl Trifluoroborates with Aryl Chlorides." Org. Lett. 2004, 6, 2649-2652
237. Antilla, J. C.; Baskin, J. M.; Barder, T. E.; Buchwald, S. L. "Copper-Diamine-Catalyzed N-Arylation of Pyrroles, Pyrazoles, Indazoles, Imidazoles and Triazoles." J. Org. Chem. 2004, 69, 5578-5587
236. Murata, M.; Buchwald, S. L. "A General and Efficient Method for the Palladium-Catalyzed Cross-Coupling of THiols and Secondary Phosphines." Tetrahedron2004, 60, 7397-7403
235. Rainka, M. P.; Aye, Y.; Buchwald, S. L. "Copper-Catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-azaheterocyclic Acid Derivitives." Proc. Natl. Ac. Sci. U.S.A. 2004, 101, 5821-5823
234. Chae, J.; Buchwald, S. L. "Palladium-Catalyzed Regioselective Hydrodebromination of Dibromoindoles: Application to the Enantioselective Synthesis of Indolodioxane U86192A." J. Org. Chem. 2004, 69, 3336-3339
233. Klapers, A.; Parris, S.; Anderson, K. W.; Buchwald, S. L. "Synthesis of Medium Ring Nitrogen Heterocycles via a Tandem Copper-Catalyzed C-N Bond Formation-Ring-Expansion Process." J. Am. Chem. Soc. 2004, 126, 3529-3533
232. Walker, S. D.; Barder, T. E.; Martinelli, J. R.; Buchwald, S. L. "A Rationally Designed Universal Catalyst for Suzuki-Miyaura Couplling Processes." Angew. Chemie Int. Ed. 2004, 43, 1871-1876

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06-05-23 08:43

Samuel Danishefsky

主页：http://www.columbia.edu/cu/chemi ... ky/group/index.html
MC 3106
work: +1 212-854-6195
fax: +1 212-854-7142
[url=mailto:sjd15@columbia.edu]sjd15@columbia.edu[/url]

Research Summary
Our research is centered on the synthesis of substances of complex structure with interesting biological activity. We concern ourselves with new synthetic strategies of applicability, not only to such target systems, but also to general problems in synthesis. The degree of stereochemical control that can be exercised, and the understanding of the origins of diasterofacial and topographical selectivity, are of continuing interest.
Going along with our interest in the synthesis of the goal systems is an increasing involvement with the mechanism of action of the target system. Often, such mechanisms can be clarified using insights gained about the nature of the target system accumulated through synthetic experiments.
Among our current areas of interest in the anticancer field are epothilone and eleutherobin. While structurally diverse, these two compounds seem to function by a taxol-like mechanism in their ability to inhibit microtubule disassembly.
Several projects are addressed to goal systems with immunochemical implications. Here, we are particularly concerned with the construction of carbohydrate-based tumor antigen vaccines. For this, we have had to become involved in extensive methodological studies in the carbohydrate area, including solid-phase synthesis. Having passed through important milestones in this regard, we have turned our full attention to total synthesis of complex carbohydrates, which can serve as matrix points of polyvalent vaccines. In fact, two of our constructs have recently gone to clinic with favorable early results.
We are also engaged in synthetic programs directed to various neurotrophic agents. The total synthesis of bicyclo- and tricycloillicinone are characteristic of our involvements in this area. In all cases, our goal is to fashion new chemistry and to apply this chemistry toward the syntheses of challenging goal structures. As we approach success in these efforts, the knowledge gathered in the synthesis effort gives us fresh insight into the nature of the target system itself, including its mode of action.
Syntheses recently completed in the Danishefsky laboratories include epothilone D, rishirilide B, radicicol, pinnaic acid, halichlorine, and antitumor vaccines designed to stop tumor recurrence, based upon multi-antigenicclustered motifs.

Back to Top
Publications
"The Total Synthesis of Rishirilide B," J.G. Allen and S.J. Danishefsky, J. Am. Chem. Soc., 123, 351352 (2001)
"Pursuit of Optimal Carbohydrate-Based Anticancer Vaccines: Preparation of a Multi-Antigenic Unimolecular Glycopeptide Containing the Tn, MBr1 and Lewisy Antigens," J.R. Allen, C.R. Harris, and S.J. Danishefsky, J. Am. Chem. Soc., 123, 18901897 (2001)
"Total Synthesis and Determination of the Absolute Configuration of Frondosin B," M. Inoue, M. Carson, A. Frontier, and S.J. Danishefsky, J. Am. Chem. Soc., 123, 18781889 (2001)
"Discovery Through Total Synthesis: A Retrospective on the Himastatin Problem," T. Kamenecka and S.J. Danishefsky, Eur. J. Chem., 7(1), 4163 (2001)
"Total Synthesis of Tumor Related Antigens N3: Probing the Feasibility Limits of the Glycal Assembly Method," H.M. Kim, I.-J. Kim, and S.J. Danishefsky, J. Am. Chem. Soc., 123, 3548 (2001)
"Synthesis of the Highly Oxygenated Tricyclic Core of Lactonamycin via Sequential Intramolecular Wessely Oxidative Lactonization‹Enol Ether Epoxidation," C. Cox and S.J. Danishefsky, Org. Letters, 2 (22), 34933496 (2000)
"On the Conformations of Halichlorine and the Pinnaic Acids: Nitrogen Inversion as a Possible Determinant of Biological Profile," D. Trauner, D.G. Churchill, and S.J. Danishefsky, Helv. Chimica Acta., 83, 23442351 (2000)
"A Rapid Total Synthesis of Spirotryprostatin B: Proof of Its Relative and Absolute Stereochemistry," F. von Nussbaum and S.J. Danishefsky, Angew. Chem. Int. Ed. Engl., 39 (12) 21752178 (2000)
"A Fully Synthetic Route to the Neurotrophic Illicinones: Syntheses of Tricycloillicinone and Bicycloillicinone Aldehyde," T.R.R. Pettus, M. Inoue, X.-T. Chen, and S. J. Danishefsky, J. Am. Chem. Soc., 122 (26), 61606168 (2000)
"From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anti-Cancer Vaccines," S.J. Danishefsky and J.R. Allen, Angewandte Chem., 39, 836863 (2000)

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06-05-23 08:44

Paul A. Wender

Bergstrom Professor of Chemistry (b. 1947)

B.S., 1969, Wilkes College; Ph.D., 1973, Yale University

N.I.H. Postdoctoral Fellow, 1974, Columbia University; A. P. Sloan Fellow, 1979; Dreyfus Teacher Scholar, 1980; Ernest Guenther Award, 1988; ICI Pharmaceutical Group's Stuart Award for Excellence in Chemistry, 1988; Arthur C. Cope Scholar Award, 1990; Alexander von Humboldt Stiftung Award, 1991; ASSU Teaching Award, 1991; Hoagland Prize for Undergraduate Teaching, Stanford, 1991; Fellow, American Academy of Arts and Sciences, 1992; Bing Teaching Award, Stanford, 1992; Pfizer Research Award for Synthetic Organic Chemistry, 1995; American Chemical Society Award for Creative work in Synthetic Organic Chemistry, 1998; Dean's Award for Distinguished Teaching, 2000; Fellow, American Association for the Advancement of Science, 2001; American Chemical Society H.C. Brown Award for Creative Research in Synthetic Methods, 2003; Member National Academy of Science, 2003.

Organic, Organometallic, Bioorganic, and Medicinal Chemistry

650-723-0208
wenderp@stanford.edu

Principal Research Interests
Our research program involves studies in chemistry, biology, and medicine. A special emphasis is placed on training and research in complex molecule synthesis and inventing new reactions and on the utilization of this expertise in addressing problems of biochemical and medicinal significance. Our studies include: 1) the design and development of new reactions, methods, reagents, and strategies that introduce fundamentally novel ways of synthesizing complex molecules of biological or medicinal significance; 2) synthetic and mechanistic organometallic chemistry with an emphasis on new catalytic reactions; 3) elucidation of the molecular mode of action of biologically and medicinally important agents; 4) the molecular basis for tumor promotion; 5) drug delivery and novel mechanisms of transport into cells including the design and development of new transporters of drugs and probes; 6) the structure of biomacromolecules; 7) medicinal chemistry; and 8) computer modeling and molecular recognition..

The key to successful syntheses is the invention or discovery of new reactions. Our studies on organometallic chemistry are directed at the development of fundamentally new concepts, methods, reagents, and reactions for organic synthesis with the goal of moving the field of complex molecule synthesis closer to the ideal of short, safe, and efficient syntheses. Studies on new metal catalyzed reactions (e.g., 4+4, 4+2, 5+2, 6+2, 6+1, 5+2+1, 2+2+1, 5+1+2+1 cycloadditions) provide an exceptional opportunity to advance the frontiers of synthesis and focus on reactions that in the absence of metal catalysts would be impossible or difficult to achieve.

Another area of emphasis is on medicinal agents like bryostatin, currently in human clinical trials for the treatment of cancer. Bryostatin represents a remarkable synthetic challenge and a lead in an as yet unknown but novel mode of action that results in stimulation of the immune system. Bryostatin appears to enhance the efficacy of many anti-cancer agents. We have designed and synthesized analogues that are up to 3 order of magnitude better than bryostatin. Efforts on this lead continue along with several other problems of comparable synthetic challenge and medicinal importance. Related opportunities at the interface of synthesis, biology and medicine include studies on kirkine, gnidimacrin and apoptolidin, molecules that represent a formidable synthetic challenge and a unique opportunity in medicine.

One of the major problems in science is developing methods for breaching biological barriers. We are also involved in investigations on new molecular transporters that allow uptake of a wide range of molecules into cells, including small molecules, proteins, and anti-sense agents. This area opens new opportunities in chemotherapy including gene therapy and establishes a new tool of exceptional breadth for studying biochemical pathways.

Our studies on molecular carcinogenesis are directed at understanding the steps leading to the development of cancer, a necessary starting point for developing cancer-prevention strategies and chemotherapeutic agents. This project places a heavy emphasis on molecular modeling of enzyme activators and inhibitors, complex molecule synthesis, protein structure, and mode of action studies.

Representative Publications
Organometallic Chemistry
J. Am. Chem. Soc. 2005, 2836; J. Am. Chem. Soc. 2004, 5948; J. Am. Chem. Soc. 2004, 9154; Angewandte Chemie Int. Ed., 2003, 1853; J. Am. Chem. Soc. 2002, 2876; J. Am. Chem. Soc. 2001, 179-180; J. Am. Chem. Soc. 2000, 7815-7816; J. Am. Chem. Soc., 1999, 10442.

Complex Molecule Total Synthesis
Proc. Natl. Acad. Sci. USA 2004, 8803; J. Am. Chem. Soc. 2002, 13648; J. Am. Chem. Soc. 2002, 4956; Organic Lett. 2000, 2323; Organic Lett., 1999, 137; J. Am. Chem. Soc.; 2002, 13648; J. Am. Chem. Soc., 1997, 12976.

3 Medicinal Chemistry, Drug Design, Biochemistry Chemistry & Biology 2004, 1261; Organic Lett. 2005, 79; Current Drug Discovery Technologies 2004, 1; Proc. Natl. Acad. Sci. USA 2004, 8803; Pure Appl. Chem. 2003, 143; J. Am. Chem. Soc. 2002, 13648; Bioorganic and Medicinal Chemistry Letters, 2001, 719-722; Pure & Appl. Chem, 1998, 539; Medicinal Research Reviews, 1999, 388; Proc. Natl. Acad. Sci. USA, 1998, 6624.

4 Drug Delivery J. Am. Chem. Soc. 2004, 9506; J. Am. Chem. Soc. 2004, 6850; Proc. Natl. Acad. Sci. USA , 2003, 14281; J. Med. Chem. 2002, 45, 3612-3618; J. Am. Chem. Soc. 2002, 13382; Natl. Acad. Sci. USA, 2000, 97, 13003-13008; Nature Medicine, 2000, 1253-1257.

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06-05-23 08:44

Professor C. Dale Poulter

主页：http://www.chem.utah.edu/faculty/poulter/Grphome.htm/index.html

Education
B.S., 1964, Louisiana State University (Cum Laude)
Ph.D., 1967, University of California at Berkeley, with W.G. Dauben
Postdoctoral, 1967-69, University of California at Los Angeles, with S. Winstein

C. Dale Poulter, John A. Widtsoe Distinguished Professor

Awards
Honorary Professor, University of Queensland, Brisbande, Australia, 2002-2004
Repligen Award, Biological Division, American Chemical Society, 2002
Wilsmore Fellow, Melbourne University, 2001
Rosenblatt Award, University of Utah, 1999
Arthur C. Cope Scholar Award, American Chemical Society, 1998
Governor's Medal for Science and Technology, 1995
National Institutes of Health Merit Award, 1995
Fellow, American Association for the Advancement of Science, 1994
Utah Award, American Chemical Society, 1992
Ernest Guenther Award, American Chemical Society, 1991
Distinguished Research Award, University of Utah, 1984
David P. Gardner Faculty Fellow, 1983
Alfred P. Sloan Fellow, 1975-79
NIH Career Development Awardee, 1975-80
NIH Postdoctoral Fellow, 1967-69
NIH Predoctoral Fellow, 1965-67
Omnicron Delta Kappa, 1964
Phi Lambda Upsilon, 1964
Phi Kappa Phi, 1964

Professional Positions
Distinguished Professor of Chemistry, University of Utah, 1996-present
Chair, Department of Chemistry, University of Utah, 1995-2000
John A. Widtsoe Professor of Chemistry, University of Utah, 1994-present
Research Professor, Department of Medicinal Chemistry, University of Utah, 1978-present
Adjunct Professor, Department of Biochemistry, University of Utah, 1986-present
Professor, Department of Chemistry, University of Utah, 1978-1994
Director, Interdepartmental Program in Biological Chemistry, 1990-1993
Associate Professor, Department of Chemistry, University of Utah, 1975-1978
Associate Research Professor, Department of Biopharmaceutical Sciences, University of Utah, 1975-1978
Assistant Professor, Department of Chemistry, University of Utah, 1969-1975
Assistant Research Professor, Department of Biopharmaceutical Sciences, University of Utah, 1971-1975
Chemist, Esso Research Laboratory, Baton Rouge, Louisiana, Summer 1964
Chemist, PPG Chemicals, Lake Charles, Louisiana, Summers, 1962, 1963
Professional Activities
NAS, Bio2010, Chemistry sub-committee, 2001
AAAS, Member-at-Large, 2001-present
CS, Advisory Committee on Graduate Education, 2000-present
ACS, Committee on Professional Training, 1996-present
ACS, Councilor, Biological Division, 1993-present
AAAS, Nominating Committee Chemistry Division, 1997-1999, Chair 1999
ACS, Chair of Organic Division, 1998
ACS, Selection Committee; Editor of Organic Letters, 1998
ACS, Committee on Science, 1996-1999
NSF, Workshop on Organic Synthesis and Natural Products, co-organizer, 1993-1995
14th Enzyme Mechanisms Conference, Scottsdale, AZ, Chair, 1993-95
13th Enzyme Mechanisms Conference, Key Largo, FL, organizing committee, 1991-97
NIH, General Medical Sciences Council, 1990
ACS, American Coordinator, Biological Program, Pacific Basin Chemical Congress, 1989, 1995
PRF, Advisory Board, 1988-1990
ACS, Selection Committee; Editor of Journal of Organic Chemistry, 1988
ACS, Program Chairman for Biological Division, 1987
ACS, Canvassing Committee, Roger Adams Award in Organic Chemistry, 1986-1990
Gordon Conference on Enzymes, Coenzymes, and Metabolic Pathways, Chair, 1985
ACS, Executive Committee Organic Division, 1983-1986
NAS, Workshop on Effort Reporting Requirements of OMB Circular A-21; 1983
NIH, Ad Hoc member and Special Study Sections; 1980-1993
7th Enzyme Mechanisms Conference; Sanibel, Florida; organizing committee, 1981-1983
ACS, Ad Hoc Task Force to monitor the Journal of Organic Chemistry; 1980-1981
NIH, Medicinal Chemistry A Study Section; 1977-81

Editorial Activities
Editor-in-Chief, Journal of Organic Chemistry, 2001- present
Senior Editor, Journal of Organic Chemistry, 2000-2001
Associate Editor, Organic Letters, 1999-2001
Associate Editor, Journal of Organic Chemistry, 1990-1995
Editorial Advisory Board, Chemical Reviews, 1996-2001
Editorial Advisory Board, Bioorganic & Medicinal Chemistry, 1993-present
Editorial Advisory Board, Journal of Organic Chemistry, 1987-1990
Editorial Board, Journal of Bioorganic Chemistry, 1983-1990
Editorial Advisory Board, Journal of the American Chemical Society, 1983-1986

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活动]有机化学家，名人，大腕巡礼 » 编辑文章

K. C. Nicolaou

http://www.scripps.edu/chem/nicolaou/

K.C. Nicolaou was born on July 5, 1946, in Cyprus where he grew up and went to school until the age of 18.  In 1964, he went to England where he spent two years learning English and preparing to enter the University. He studied chemistry at the University of London. (B.Sc., 1969, Bedford College; Ph.D. 1972, University College, with Professors F. Sondheimer and P.J. Garratt)  In 1972, he moved to the United States and, after postdoctoral appointments at Columbia University (1972-1973, Professor T.J. Katz) and Harvard University (1973-1976, Professor E.J. Corey), he joined the faculty at the University of Pennsylvania where he rose through the ranks to become the Rhodes-Thompson Professor of Chemistry.

In 1989, he accepted joint appointments at the University of California, San Diego, where he is Professor of Chemistry, and The Scripps Research Institute where he is the Darlene Shiley Professor of Chemistry, and Chairman of the Department of Chemistry. In 1996, he was appointed Aline W. and L.S. Skaggs Professor of Chemical Biology in The Skaggs Institute for Chemical Biology, The Scripps Research Institute. He serves on the Scientific Advisory Board of numerous scientific journals and is an advisor to several biotechnology and pharmaceutical companies. K.C. Nicolaou's research interests include the chemistry, biology, and medicine of natural and designed molecules. The group's research activities are centered around the total synthesis of architecturally novel and biologically important natural products which serve as opportunities for discovery and invention of novel synthetic strategies, methods, and enabling technologies for biology and medicine.  He is the author or co-author of almost six hundred publications, fifty-five patents and three books. Among K.C. Nicolaou's Awards and Honors are the Schering Prize (Germany), the Aspirin Prize (Spain), the Max Tishler Prize Lecture (Harvard), the Yamada Prize (Japan), the Janssen Prize (Belgium), the Nagoya Medal (Japan), the Centenary Medal (Royal Society UK), the Paul Karrer Medal (Switzerland), the Inhoffen Medal (Germany), the Nichols Medal (USA), the Linus Pauling Medal (USA),  the Esselen Award (USA), the ACS Award for Creative Work in Synthetic Organic Chemistry (USA), the ACS Guenther Award in Natural Products Chemistry (USA), the Nobel Laureate Signature Award, Tetrahedron Prize Award, and several honorary degrees. He is a Fellow of the American Academy of Arts and Sciences and a Member of the National Academy of Sciences

  Awards
Arthur C. Cope Award, American Chemical Society, 2005

Honorary Fellowship, Chemical Research Society of India, 2004

Aristeio Bodossaki Prize, Bodossaki Foundation, Greece, 2004

Honorary Ph.D. (honoris causa) from the University of Rome, La Sapienza, Italy 2003

Nobel Laureate Signature Award for Graduate Education in Chemistry, shared with Phil S. Baran, American Chemical Society, USA, 2003

Tetrahedron Prize for Creativity in Organic Chemistry, 2002

Foreign Member, Academy of Athens, Greece, 2001

Greek American Scientists, Engineers, and High Tech Entrepeneurs Award, 2001

Nagoya Medal of Organic Chemistry, Nagoya University, Nagoya, Japan, 2001

Ernst Schering Prize, Ernst Schering Research Foundation, 2001

Nagoya Medal of Organic Chemistry, Nagoya University, Nagoya, Japan, 2001

Centenary Medal, Royal Society of Chemistry, United Kingdom, 2000-2001

Honorary Ph.D. (honoris causa) from the Agricultural University of  Athens, Greece, 2000

Paul Karrer Gold Medal, Switzerland, 2000

Max Tishler Prize Lecture, Harvard University, USA, 2000

Yamada Prize, Japan, 1999

Honorary Professorship from the Shanghai Institute of Organic Chemistry, China, 1999

Elected to Rank of Fellow, American Association for the Advancement of Science, USA, 1999

Aspirin Prize for Solidarity through Chemistry, Spain, 1999

Press Club Headliner Award, San Diego Press Club, USA, 1998

Honorary Ph.D. (honoris causa) from the University of Crete, Greece, 1998

Gustavus John Esselen Award for Chemistry in the Public Interest, American Chemical Society, Northeastern Section, USA, 1998

Decoration of the Order of the Commander of Honor Medal bestowed by the President of Greece, 1998

Honorary Ph.D. (honoris causa) from the Universidad de Alcala, Madrid, Spain, 1998

Cliff S. Hamilton Award in Organic Chemistry, University of Nebraska, Lincoln, 1997

Distinguished Scientist Award, American Chemical Society, San Diego Section, USA, 1997

Honorary Ph.D. (honoris causa) from the University of Cyprus, Cyprus, 1997

Honorary Member of the Pharmaceutical Society of Japan, 1996

Honorary Ph.D. (honoris causa) from the University of Thessaloniki, Greece, 1996

Linus Pauling Medal, American Chemical Society, Puget Sound, Portland, and Oregon Section, USA, 1996

Member of the National Academy of Sciences, USA, 1996

Inhoffen Medal of the Gesellshaft fuer Biotechnologische Forschung mbH (GBF) and the Technical University of Braunschweig, Germany, 1996

Chemical Pioneer of the American Institute of Chemists Award, USA, 1996

Ernest Guenther Award in the Chemistry of Natural Products, American Chemical Society, USA, 1996

William H. Nichols Medal, American Chemical Society, New York Section, USA, 1996

Rhone-Poulenc Silver Medal of the Royal Society of Chemistry, United Kingdom 1995

Honorary Ph.D. (honoris causa) from the University of Athens, Greece, 1995

D.Sc. degree, University of London, United Kingdom, 1994

Karavas Prize, Cyprus, 1994

Alexander the Great Award, Hellenic Cultural Society of San Diego, USA, 1994

Paul Janssen Prize for Creativity in Organic Synthesis, Belgium, 1994

Fellow of the American Academy of Arts and Sciences, USA, 1993

Award for Creative Work in Synthetic Organic Chemistry, American Chemical Society, USA, 1993

Alan R. Day Award, Philadelphia Organic Chemist's Club, USA, 1993

Japan Society for the Promotion of Science Award, Japan, 1988

Fellow of the New York Academy of Sciences, USA, 1987

Alexander von Humboldt Foundation US Senior Scientist Award, Germany, 1987-1988

Arthur C. Cope Scholar Award, American Chemical Society, USA, 1987

American Chemical Society Philadelphia Section Award, USA, 1983

J.S. Guggenheim Fellow, USA, 1984

Honorary M.A. (honoris causa) from the University of Pennsylvania, USA, 1980

Camille and Henry Dreyfus Teacher-Scholar Award, USA, 1980-1984

A.P. Sloan Fellowship, USA, 1979-1983
Selected Publications:

559. Cascade Reactions in Total Synthesis, K.C. Nicolaou and S.A. Snyder, L'Actualite Chimique, 83-88 (2003).

560. Natural Products and Chemical Synthesis at the Forefront of the Fight Against Cancer, K.C. Nicolaou, T. Montagnon, G.E. Vassilikogiannakis, Bio, April-June (5), 22-30 (2003).(Greek)

561. Synthetic Studies on Thiostrepton: Construction of Thiostrepton Analogues with the Thiazoline-Containing Macrocycle, K.C. Nicolaou, M. Nevalainen, M. Zak, S. Bulat, M. Bella, B.S. Safina, Angew. Chem. Int. Ed. 42, 3418-3424 (2003).

562. Design, Synthesis and Biological Evaluation of Highly Potent Epothilone B Analogs, K.C. Nicolaou, P.K. Sasmal, G. Rassias, M.V. Reddy, K.-H. Altmann, M. Wartmann, A. O'Brate, P. Giannakakou, Angew. Chem. Int. Ed. 42, 3515-3520 (2003).

563. Synthesis of Complex Carbohydrates: Everninomicin 13,384-1, K.C. Nicolaou, H.J. Mitchell, S.A. Snyder, in Carbohydrate-based Drug Discovery, Vol. 1, C.-H.Wong, Ed., Wiley-VCH, Weinheim, Ch. 8, pp. 215-252, 2003.

564. Studies Towards the Synthesis of Azadirachtin: Enantioselective Entry Into the Azadirachtin Framework via Cascade Reactions, K.C. Nicolaou, A.J. Roecker, H. Monenschein, P. Guntupalli, M. Follmann, Angew. Chem. Int. Ed. 42, 3637-3642 (2003).

565. Total Synthesis of the Proposed Azaspiracid-1 Structure, Part 1: Construction of Enantiomerically Pure C1-C20, C21-C27 and C28-C40 Fragments, K.C. Nicolaou, Y. Li, N. Uesaka, T.V. Koftis, S. Vyskocil, T. Ling, M. Govindasamy, W. Qian, F. Bernal, D.Y.-K. Chen, Angew. Chem. Int. Ed. 42, 3643-3648 (2003).

566. Total Synthesis of the Proposed Azaspiracid-1 Structure, Part 2: Coupling of C1-C20, C21-C27 and C28-C40 Fragments and Completion of the Synthesis, K.C. Nicolaou, D.Y.-K. Chen, Y. Li, W. Qian, T. Ling, S. Vyskocil, T.V. Koftis, M. Govindasamy, N. Uesaka, Angew. Chem. Int. Ed. 42, 3649-3653 (2003).

567. Perspectives in Total Synthesis: a Personal Account, K.C. Nicolaou, Tetrahedron 59, 6683-6738 (2003).

568. The Olefin Metathesis Reaction in Complex Molecule Construction, K.C. Nicolaou and S.A. Snyder, in Handbook of Metathesis, Vol 2, R.H. Grubbs, Ed., Wiley-VCH, Weinheim, Ch. 2.9, 323-337, 2003.

569. New Reactions of IBX: Oxidation of Nitrogen- and Sulfur-Containing Substrates to Afford Useful Synthetic Intermediates, K.C. Nicolaou, C.J.N. Mathison, T. Montagnon, Angew. Chem. Int. Ed. 42, 4077-4082 (2003).

570. Total Synthesis of 1-O-Methyllateriflorone, K.C. Nicolaou, P.K. Sasmal, H. Xu, K. Namoto, A. Ritzén, Angew. Chem. Int. Ed. 42, 4225-4229 (2003).

571. Total Synthesis and Biological Evaluation of (-)-Apicularen A and Analogs Thereof, K.C. Nicolaou, D.W. Kim, R. Baati, A. O'Brate, P. Giannakakou, Chem. Eur. J. 9, 6177-6191 (2003).

572. Total Synthesis of Apoptolidin: Construction of Enantiomerically Pure Fragments, K.C. Nicolaou, K.C. Fylaktakidou, H. Monenschein, Y. Li, B. Weyershausen, H.J. Mitchell, H. Wei, P. Guntupalli, D. Hepworth, K. Sugita, J. Am. Chem. Soc., 125, 15433-15442 (2003).

573. Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation, K.C. Nicolaou, Y. Li, K. Sugita, H. Monenschein, P. Guntupalli, H.J. Mitchell, K.C. Fylaktakidou, D. Vourloumis, P. Giannakakou, A. O'Brate, J. Am. Chem. Soc., 125, 15443-15454 (2003).

574. Total Synthesis of Hybocarpone and Analogues Thereof. A Facile Dimerization of Naphthazarins to Pentacyclic Systems, K.C. Nicolaou, D.L.F. Gray, J. Am. Chem. Soc., 126, 607-612 (2004).

575. Total Synthesis of Hamigerans and Analogues Thereof. Photochemical Generation and Diels Alder Trapping of Hydroxy-o-quinodimethanes, K.C. Nicolaou, D.L.F. Gray, J. Tae, J. Am. Chem. Soc., 126, 613-627 (2004).

576. Interaction of Epothilone Analogs with Paclitaxel Binding Site: Relationship Between Binding Affinity, Microtubule Stabilization, and Cytotoxicity, R.M. Buey, J.F. Díaz, J.M. Andreu, A. O'Brate, P. Giannakakou, K.C. Nicolaou, P.K. Sasmal, A. Ritzén, K. Namoto, Chem. Biol., 11, 225-236 (2004).

577. o-Iodoxybenzoic Acid (IBX) as a Viable Reagent in the Manipulation of Nitrogen- and Sulfur-Containing Substrates: Scope, Generality and Mechanism of IBX-Mediated Amine Oxidations and Dithiane Deprotections, K.C. Nicolaou, C.J.N. Mathison, T. Montagnon, J. Am. Chem. Soc., 126, 5192-5201 (2004).

578. Biomimetically Inspired Total Synthesis and Structure Activity Relationships of 1-O-Methyllateriflorone. 6p Electrocyclizations in Organic Synthesis, K.C. Nicolaou, P.K. Sasmal, H. Xu, J. Am. Chem. Soc., 126, 5493-5501 (2004).

579. A New Method for the Stereoselective Synthesis of - and -Glycosylamines Using the Burgess Reagent, K.C. Nicolaou, S.A. Snyder, A.Z. Nalbandian, D.A. Longbottom, J. Am. Chem. Soc. 126, 6234-6235 (2004).

580. Structural Revision and Total Synthesis of Azaspiracid-1. Part 1: Intelligence Gathering and Tentative Proposal, K.C. Nicolaou, S. Vyskocil, T.V. Koftis, Y.M.A. Yamada, T. Ling, D.Y.-K. Chen, W. Tang, G. Petrovic, M.O. Frederick, Y. Li, M. Satake, Angew. Chem. Int. Ed. 43, 4312-4318 (2004).

581. Structural Revision and Total Synthesis of Azaspiracid-1. Part 2: Definition of the ABCD Domain and Total Synthesis, K.C. Nicolaou, T.V. Koftis, S. Vyskocil, G. Petrovic, T. Ling, Y.M.A. Yamada, W. Tang, M.O. Frederick, Angew. Chem. Int. Ed. 43, 4318-4324 (2004).

582. The Essence of Total Synthesis, K.C. Nicolaou, S.A. Snyder, PNAS, 101, 11929-11936 (2004).

583. Studies Towards Diazonamide A: Initial Synthetic Forays Directed Towards the Originally Proposed Structure, K.C. Nicolaou, S.A. Snyder, X. Huang, K.B. Simonsen, A.E. Koumbis, A. Bigot, J. Am. Chem. Soc. 126, 10162-10173 (2004).

584. Studies Towards Diazonamide A: Development of a Hetero Pinacol Macrocyclization Cascade for the Construction of the Bis-Macrocyclic Framework of the Originally Proposed Structure, K.C. Nicolaou, S.A. Snyder, N. Giuseppone, X. Huang, M. Bella, M.V. Reddy, P. Bheema Rao, A.E. Koumbis, P. Giannakakou, A. O'Brate, J. Am. Chem. Soc. 126, 10174-10182 (2004).

585. Chemistry and Biology of Diazonamide A: First Total Synthesis and Confirmation of the True Structure, K.C. Nicolaou, D.Y.-K. Chen, X. Huang, T. Ling, M. Bella, S.A. Snyder, J. Am. Chem. Soc., ASAP.

586. Chemistry and Biology of Diazonamide A: Second Total Synthesis of Diazonamide A and Biological Investigations, K.C. Nicolaou, J. Hao, M.V. Reddy, P. Bheema Rao, G. Rassias, S.A. Snyder, X. Huang, D.Y.-K. Chen, W.E. Brenzovich, N. Giuseppone, P. Giannakakou, A. O'Brate, J. Am. Chem. Soc., ASAP.

587. Total Synthesis of Thiostrepton, Part 1: Construction of the Dihydropiperidine Thiazoline-Containing Macrocycle, K.C. Nicolaou, B.S. Safina, M. Zak, A.A. Estrada, S.H. Lee, Angew. Chem. Int. Ed. 43, 5087-5092 (2004).

588. Total Synthesis of Thiostrepton, Part 2: Construction of the Quinaldic Acid-Containing Macrocycle and Completion of the Synthesis, K.C. Nicolaou, M. Zak, B.S. Safina, S.H. Lee, A.A. Estrada, Angew. Chem. Int. Ed. 43, 5092-5097 (2004).

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06-05-23 08:45

John F. Hartwig

HOMEPAGE

Professor Hartwig received his A. B. degree from Princeton, in 1986 and his Ph.D. from the University of California, Berkeley in 1990. Subsequently, he was an American Cancer Society Postdoctoral Fellow at the Massachusetts Institute of Technology and joined the Yale University faculty in 1992. Dr. Hartwig will join the University of Illinois chemistry faculty in July 2006.

Honors and Awards:
ACS Award in Organometallic Chemistry, 2006
Thieme-IUPAC Prize in Synthetic Organic Chemistry, 2004
Leo Hendrik Baekeland Award, 2003
A. C. Cope Scholar, 1997
Eli Lilly Grantee, 1997
Camille Dreyfus Teacher-Scholar Award, 1997
Alfred P. Sloan Research Fellow, 1996-1998
Union Carbide Innovative Recognition Award, 1995-1996
NSF Young Investigator Award, 1994
DuPont Young Professor Award, 1993
Dreyfus Foundation New Faculty Award, 1992

Representative Publications:
"A General and Long-Lived Catalyst for the Palladium-Catalyzed Coupling of Aryl Halides with Thiols" M. A. Fernández-Rodríguez, Q. Shen, J. F. Hartwig, J. Am. Chem. Soc. (2006, ASAP).

Hartwig, J. F., Synthetic Chemistry: Recipes for Excess. Nature, 2005. 437: p. 487-488

Zhao, J., Goldman, A. S., and J. F. Hartwig, Oxidative Addition of Ammonia to Form a Stable Monomeric Amido Hydride Complex. Science, 2005. 307(5712): p. 1080-1082.

"Mild Palladium-Catalyzed Selective Monoarylation of Nitriles" L. Wu, J. F. Hartwig, J. Am. Chem. Soc., 127, 15824-15832 (2005).

"Mechanism of the Mild Functionalization of Arenes by Diboron Reagents Catalyzed by Iridium Complexes. Intermediacy and Chemistry of Bipyridine-Ligated Iridium Trisboryl Complexes," T. M. Boller, J. M. Murphy, M. Hapke, T. Ishiyama, N. Miyaura, and J. F. Hartwig, J. Am. Chem. Soc., 127, 14263-14278 (2005).

"Mechanistic Studies of Ruthenium-Catalyzed Anti-Markovnikov Hydroamination of Vinylarenes: Intermediates and Evidence for Catalysis through Pi-Arene Complexes," J. Takaya and J. F. Hartwig, J. Am. Chem. Soc., 127, 5756-5757 (2005).

"Iridium-Catalyzed Regio- and Enantioselective Allylation of Ketone Enolates" T. Graening, J. F. Hartwig, J. Am. Chem. Soc. (Communication), 127, 17192-1793 (2005).

Culkin, D. A. and J. F. Hartwig, Palladium-catalyzed alpha-arylation of carbonyl compounds and nitriles. Accounts of Chemical Research, 2003. 36(4): p. 234-245.

"Fluorescence Resonance Energy Transfer (FRET) as a High-Throughput Assay for Coupling Reactions. Arylation of Amines as a Case Study," Stauffer, S. R., Hartwig, J. F. J. Am. Chem. Soc., 125, 6977-6985 (2003).

Hartwig, J. F., Raising the bar for the "Perfect reaction". Science, 2002. 297(5587): p. 1653-1654.

Chen, H. Y., Schlecht, S., Semple, T. C., and J. F. Hartwig, Thermal, catalytic, regiospecific functionalization of alkanes. Science, 2000. 287(5460): p. 1995-1997.

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06-05-23 08:47

终于看见个中国的~~~~~~~~~`

麻生明院士

1965年5月出生于浙江省东阳县，中国科学院上海有机化学研究所研究员，博士生导师，金属有机化学国家重点实验室主任,2003年2月起被浙江大学（长江特聘教授）和上海有机化学研究所共聘。2005年12月当选为中国科学院(化学部)院士。

Tel.：54925147

Fax： 64167510

E-mail: masm@mail.sioc.ac.cn

教育 Education:

1986年毕业于杭州大学化学系
1990年获中科院上海有机化学所博士学位

工作经历 Experience:

1992年9月赴瑞士苏黎世联邦理工大学从事博士后研究
1993年10月赴美国Purdue大学继续博士后研究
1997年回国, 年底被中科院上海有机化学所聘为研究员、博士生导师
2003年2月起按双方单位协议被浙江大学（长江特聘教授）和中科院上海有机化学所共聘。

社会兼职 Social Position:

真正重要的Angew. Chem. Int. Ed. 这个德国应用化学的中国区两位编辑之一

2003-    国际刊物Tetrahedron Lett. 和Tetrahedron两个杂志的senior referee

2000-    <<中国化学>>的常务副主编

2005, 1, 1- 2010, 1, 1 Editorial Advisory Board the Bulletin of the
Chemical Society of Japan

2004,12- OMCOS 13 国际顾问委员会成员

获奖 Award:

1. 1991年获中科院院长奖学金特别奖

2. 1992年获中国科学院自然科学一等奖(一般参加)

3. 1994年获Research Accomplishments Award

4. 1997年获中国科学院自然科学一等奖(排名第二)

5. 1999年获中国科学院青年科学家奖一等奖

6. 1999年获求是基金杰出青年学者奖

7. 1999年国家自然科学二等奖 (排名第二)

8. 1999年中国科学院十大杰出青年

9. 1999年中国化学会青年化学奖

10．2003全国留学回国人员成就奖

11．2003年中国科学院优秀研究生导师奖

12．2004年上海优秀留学回国人才

13．2004中国科学院优秀研究生指导教师

14．2004获得the 2004 Chan Award for Outstanding Young Organic Chemist

15．2004年中国化学会有机化学专业委员会“有机合成创造奖”

16．2004年国家重点实验室计划先进个人

17．2004年上海市科技进步一等奖(排名第一)

18．2004年第五届上海市自然科学牡丹奖

19．2005年获得OMCOS 13 Award(1997年至2001年称为“Springer Award”)

研究领域 Research field:

麻生明的主要工作为：：(1) 金属参与的联烯化学：(i) 缺电子联烯的氢卤化反应和(ii) 官能团化联烯的多组份偶联关环反应；(2) 联烯亲电加成反应的立体化学及区域选择性调控；(3) 亚烷基环丙烷及环丙烯的选择性碳-碳键断裂。

麻生明是国家973项目“创造新物质的分子工程学”的首席科学家之一，陆续主持了基金委重点项目、国际合作重大项目、优秀实验室项目、杰出青年基金项目和中科院“创新方向性项目”、“九五”重大基础研究等项目。

独立工作以来共发表论文137篇。其中Chem. Rev. 上1篇，Acc. Chem. Res.上1篇，J. Am. Chem. Soc.上8篇，Angew. Chem.上9篇， Chem. Eur. J.上6篇。撰写中文专著1本，合作编写中文专著1本，撰写英文章节4章。

代表性论文目录：

1. Pd(0)-catalyzed Insertion-Cyclization Reaction of 2,3-Allenols with Aryl or Alkenyl Halides. Diastereoselective Synthesis of Highly Optically Active trans-2,3-Disubstituted Vinylic Oxiranes

Shengming Ma* and Shimin Zhao

J. Am. Chem. Soc. 1999, 121, 7943-7944.



2. Novel Substituent and Chelating Effects in the Pd-Catalyzed Reaction of 2,3-Allenols, Aryl Iodides, and Amines. Highly Regio- and Stereo-selective Synthesis of 2-Amino-3-alken-1-ols or 4-Amino-2(E)-alken-1-ols

Shengming Ma* and Shimin Zhao

J. Am. Chem. Soc. 2001，123，5578-5579.



3. Highly Regio- and Stereoselective Halohydroxylation Reaction of 1,2-Allenyl Phenyl Sulfoxides. Reaction Scope, Mechanism and the Corresponding Pd- or Ni-Catalyzed Selective Coupling Reactions

Shengming Ma,* Hongjun Ren, and Qi Wei

J. Am. Chem. Soc. 2003, 125, 4817-4830.



4. 2,3,4- or 2,3,5-Trisubstituted Furans: Catalyst-Controlled Highly Regioselectively Ring-Opening Cycloisomerization Reaction of Cyclopropenyl Ketones

Shengming Ma* and Junliang Zhang

J. Am. Chem. Soc. 2003, 125, 12386-12387.



5. A Novel X- (X=I, Br)-Triggered Ring-opening Coupling Reaction of Cyclopropenes with Organic Halides

Shengming Ma*, Junliang Zhang, Yangjun Cai and Lianghua Lu

J. Am. Chem. Soc. 2003, 125, 13954-13955.



6. Catalytic Regioselectivity Control in Ring-Opening Cycloisomerization of Methylene- or Alkylidenecyclopropyl Ketones
Shengming Ma*, Lianghua Lu, Junliang Zhang
J. Am. Chem. Soc. 2004; 126, 9645-9660.



7. PdCl2-Catalyzed Two-Component Cross-coupling Cyclization of 2,3-Allenoic Acids and 2,3-Allenols. An Efficient Synthesis of 4-(1’, 3’-Dien-2’-yl)-2-furanone Derivatives

Shengming Ma* and Zhenhua Gu

J. Am. Chem. Soc. 2005, 127, 6182-6183.



8. ESI-MS Studies on the Mechanism of Pd(0)-Catalyzed Three-Component Tandem Double Addition-Cyclization Reaction

Hao Guo,a Rong Qian,b Yuanxi Liao,b Shengming Ma,a* and Yinlong Guob*

J. Am. Chem. Soc. 2005, 127, 13060.



9. Novel Oxidative Cyclization/Dimerization Reaction of 2,3-Allenoic Acids and 1,2-Allenyl Ketones. An Efficient Synthesis of 4-(3’-Furanyl)butenolide Derivatives

Shengming Ma* and Zhanqian Yu

Angew. Chem. Int. Ed. 2002, 41, 1775-1778.



10. Palladium(0)-Catalyzed Three-Component Tandem Double-Addition-Cyclization Reaction: Stereoselective Synthesis of cis-Pyrrolidine Derivatives

Shengming Ma* and Ning Jiao

Angew. Chem. Int. Ed. 2002, 41, 4737-4740.



11. Tuning the Regioselectivity in Palladium(II)-Catalyzed Isomerization of Alkylidenecyclopropyl Ketones. A Dramatic Salt Effect

Shengming Ma* and Junliang Zhang

Angew. Chem. Int. Ed., 2003, 42, 183-187.



12. Regioselectivity Control by a Ligand Switch in the Coupling Reaction Involving Allenic/Propargylic Palladium Species

Shengming Ma* and Guanwei Wang

Angew. Chem. Int. Ed. 2003, 42, 4215-4217.



13. Walking of C-C-p-Bond over Long Distances in Pd-Catalyzed Reactions of 2,3-Allenoic Acids with (w-1)-Alkenyl Halides

Shengming Ma* and Zhanqian Yu

Angew. Chem. Int. Ed. 2003, 42, 1955-1957.



14. A Novel 1,3-lithium Shift of Propargylic/Allenylic Lithium and the Subsequent Transmetalation/Coupling Reaction with Aryl Halides

Shengming Ma* and Qiwen He

Angew. Chem. Int. Ed. 2004, 43, 988-990.



15. Probing the Mechanism of Palladium-Catalyzed Addition of Organoboronic Acids to Allenes in the Presence of AcOH with

ESI-FTMS

Rong Qian, Hao Guo, Yuanxi Liao, Yinlong Guo,* and Shengming Ma*

Angew. Chem. Int. Ed. 2005, 44, 4771-4774.



16. What Can a Metal Catalyst Do with Allenes? One-Step Building Up of New Steroid Scaffold from Easily Available Starting Materials

Shengming Ma*, Ping Lu, Lianghua Lu, Hairong Hou, Jiemin Wei, Qiwen He, Zhenhua Gu, Xuefeng Jiang, and Xing Jin

Angew. Chem. Int. Ed. 2005, 44, 5275-5278.

　

17. 1,4-Migration of Rhodium and Palladium in Catalytic Organometallic Reactions

Shengming Ma* and Zhenhua Gu

Angew. Chem. Int. Ed. 2005, 44, 7512-7517.

　

18. Transition Metal-Catalyzed/Mediated Reaction of Allenes with A Nucleophilic Functionality Connected to the a-Carbon Atom

Shengming Ma*

Acc. Chem. Res. 2003, 36, 701-712.



19.  Some Typical Advances in the Synthetic Applications of Allenes

Shengming Ma

Chem. Rev. 2005, 105, 2829-2871.



20. Pd(II)-Catalyzed Oxidative Dimeric Cyclizative Coupling Reaction of 2,3-Allenoic Acids. An Efficient Synthesis of Bi-butenolide Derivatives

Shengming Ma*, Zhanqian Yu, and Zhenhua Gu

Chem. Eur. J. 2005, 11, 2351-2356.

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06-05-24 09:57

默默崇敬ing!

生命的意义在于，要么灌水，要么被灌！

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06-05-24 10:03

没个认识的！

生意还很小，朋友却不少。
钞票赚不到，老婆也难找。
经营玻璃仪器，化学试剂，实验器材及部分化工原料

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都没听过啊

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06-05-30 21:58

有点晕！

咋全是洋人呢？！！

Email:zmtdyx@mail.china.com QQ:445090511

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07-02-07 22:02

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08-06-08 12:12

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08-06-10 16:59

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引用:

原帖由 ma0106 于 06-05-24 10:50 发表
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